Detection of light stimulus involved in sensory perception

Across TCGA cell cohorts, RNA activity of the Detection of light stimulus involved in sensory perception pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANAPC2, ERP44, and HSD17B7P2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANAPC2 grouped by Detection of light stimulus involved in sensory perception-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ANAPC2 →	-0.428	-1.737	.004	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	ERP44 →	-0.096	-0.634	.006	.002	3	3
BREAST	HSD17B7P2 →	+0.212	+2.099	.005	<.001	3	3
LUNG_NSCLC_LUAD	TSSK1B →	+0.305	+1.616	<.001	<.001	3	2
LUNG_NSCLC_LUAD	PACC1 →	-0.335	-1.969	<.001	<.001	3	2
LUNG_NSCLC_LUAD	ANO8 →	-0.195	-1.344	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANAPC2 by Detection of light stimulus involved in sensory perception activity — LUNG_NSCLC_LUAD

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