Detection of light stimulus involved in sensory perception

Across TCGA cell cohorts, RNA activity of the Detection of light stimulus involved in sensory perception pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTFR1L, GORASP2, and EPC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of light stimulus involved in sensory perception activity versus MTFR1L in LUNG_NSCLC_LUAD (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MTFR1L →	-0.739	-1.245	.008	.001	3	4
STOMACH	GORASP2 →	+0.520	+2.035	.006	<.001	3	4
LUNG_NSCLC_LUAD	EPC1 →	-0.591	-1.100	.006	.003	3	4
BREAST	MAP7D3 →	-2.716	-1.694	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	TSPAN12 →	+2.186	+0.647	.003	.001	3	3
UPPER_AERODIGESTIVE_TRACT	HBEGF →	-2.820	-0.517	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050962 vs MTFR1L — LUNG_NSCLC_LUAD

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