Equilibrioception

Across TCGA patient cohorts, RNA activity of the Equilibrioception pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PODXL, ACBD5, and DHX30, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Equilibrioception activity versus PODXL in CCRCC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PODXL →	-0.440	-0.091	.003	.004	3	4
CCRCC	ACBD5 →	+0.306	+0.099	<.001	.003	3	4
BRCA	DHX30 →	-0.315	-0.378	<.001	.005	3	4
COAD	GOLPH3L →	+0.341	+0.093	<.001	<.001	3	4
COAD	GCC2 →	+0.239	+0.071	.001	.004	3	4
COAD	PTK7 →	-0.408	-0.072	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050957 vs PODXL — CCRCC

Explore this scatter interactively →