Equilibrioception

Across TCGA patient cohorts, RNA activity of the Equilibrioception pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDHD3, DDC, and FBXO32, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Equilibrioception activity versus HDHD3 in CCRCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HDHD3 →	+0.510	+0.363	<.001	<.001	3	3
PDAC	DDC →	+1.488	+1.089	<.001	<.001	3	3
COAD	FBXO32 →	-1.042	-0.136	.001	.003	3	3
COAD	GREM1 →	-1.113	-0.130	.006	.004	3	3
CCRCC	ANKS4B →	+1.742	+0.523	<.001	<.001	3	3
PDAC	ARL4C →	-0.948	-0.932	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050957 vs HDHD3 — CCRCC

Explore this scatter interactively →