Equilibrioception

Across TCGA cell cohorts, RNA activity of the Equilibrioception pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRS3, DYRK3, and APLF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FRS3 grouped by Equilibrioception-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FRS3 →	-0.524	-0.952	.004	.009	3	4
SKIN	DYRK3 →	-0.738	-1.050	<.001	.002	2	5
SKIN	APLF →	-0.334	-0.755	.006	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ENY2 →	-1.444	-1.839	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ANP32E →	-1.298	-1.811	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	NTAN1 →	-1.078	-1.357	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FRS3 by Equilibrioception activity — SKIN

Explore this box plot interactively →