Equilibrioception

Across TCGA cell cohorts, RNA activity of the Equilibrioception pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARK1, UGP2, and PPDPF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MARK1 grouped by Equilibrioception-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MARK1 →	-0.140	-0.677	.004	.006	3	4
BONE	UGP2 →	-0.267	-2.297	.002	<.001	3	4
LUNG_NSCLC_LUSC	PPDPF →	+0.360	+0.348	.003	.002	3	4
STOMACH	PRIM2 →	+0.410	+1.763	<.001	<.001	3	4
LUNG_NSCLC_LUAD	MED12 →	+0.295	+0.452	.001	.007	3	4
LARGE_INTESTINE	KDM6A →	+0.197	+1.384	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MARK1 by Equilibrioception activity — OVARY

Explore this box plot interactively →