Sensory perception of mechanical stimulus

Across TCGA cell cohorts, RNA activity of the Sensory perception of mechanical stimulus pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDAH, LIMD2, and MBLAC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory perception of mechanical stimulus activity versus LDAH in SOFT_TISSUE (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LDAH →	-0.917	-0.321	.003	<.001	3	3
SOFT_TISSUE	LIMD2 →	-2.360	-0.413	.003	.009	3	3
SOFT_TISSUE	MBLAC1 →	+0.621	+0.295	.003	.002	3	3
CNS	UGDH →	+0.813	+0.146	.007	.003	3	3
CNS	HMGA2 →	+2.530	+0.143	.003	.006	2	4
OESOPHAGUS	TAF2 →	+0.496	+0.203	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050954 vs LDAH — SOFT_TISSUE

Explore this scatter interactively →