Sensory perception of light stimulus

Across TCGA patient cohorts, RNA activity of the Sensory perception of light stimulus pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO1A, MAP4K1, and SLAMF1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory perception of light stimulus activity versus CORO1A in TGCT (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	CORO1A →	-1.216	-0.017	<.001	<.001	3	20
SCLC	MAP4K1 →	-1.690	-0.048	<.001	.001	3	20
THYM	SLAMF1 →	-1.774	-0.016	<.001	<.001	3	20
TGCT	HCST →	-1.150	-0.016	<.001	<.001	3	20
THYM	SIT1 →	-1.813	-0.019	<.001	<.001	3	20
TGCT	CD72 →	-0.879	-0.014	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050953 vs CORO1A — TGCT

Explore this scatter interactively →