Sensory perception of light stimulus

Across TCGA cell cohorts, RNA activity of the Sensory perception of light stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLK6, CRABP2, and CDPF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory perception of light stimulus activity versus KLK6 in OVARY (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KLK6 →	+3.463	+0.477	.001	.002	3	5
PANCREAS	CRABP2 →	+2.656	+0.304	.009	.001	3	5
BREAST	CDPF1 →	-0.614	-0.203	.001	.005	3	5
OVARY	EPS8L1 →	+3.471	+0.780	.003	.007	3	4
OVARY	KRT8 →	+3.149	+0.430	.001	.007	3	4
OVARY	MOB3A →	-0.959	-0.606	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050953 vs KLK6 — OVARY

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