Sensory perception of temperature stimulus

Across TCGA patient cohorts, RNA activity of the Sensory perception of temperature stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETDB1_S1066, SPTBN1_S1388, and BAG6_S996, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory perception of temperature stimulus activity versus SETDB1_S1066 in PDAC (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SETDB1_S1066 →	-0.728	-0.755	<.001	<.001	3	3
OV	SPTBN1_S1388 →	+1.284	+1.359	<.001	.001	3	3
UCEC	BAG6_S996 →	-2.132	-1.673	<.001	<.001	3	3
GBM	IFI16_S153 →	-0.334	-0.481	<.001	<.001	3	3
OV	POLA1_S209 →	-0.850	-0.769	<.001	.002	2	4
OV	TNRC6A_S739 →	-1.406	-1.141	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050951 vs SETDB1_S1066 — PDAC

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