Regulation of positive chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of positive chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP15, BTK, and WDFY4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of positive chemotaxis activity versus ARHGAP15 in HNSC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ARHGAP15 →	+0.768	+0.272	<.001	.006	3	8
LSCC	BTK →	+0.787	+0.804	<.001	<.001	3	7
HNSC	WDFY4 →	+0.798	+0.306	<.001	.002	3	7
UCEC	GMFG →	+0.727	+0.817	.005	<.001	3	7
LSCC	TESPA1 →	+0.651	+0.805	<.001	<.001	3	7
HNSC	SELPLG →	+0.966	+0.351	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050926 vs ARHGAP15 — HNSC

Explore this scatter interactively →