Regulation of positive chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of positive chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100PBP, DUSP19, and NR2C2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, S100PBP grouped by Regulation of positive chemotaxis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	S100PBP →	+0.530	+0.777	.002	.005	3	5
LUNG_NSCLC_LUAD	DUSP19 →	+0.547	+0.869	.002	.001	3	5
LUNG_SCLC	NR2C2 →	+0.615	+0.823	.009	.006	3	4
LUNG_SCLC	DDX39B →	+0.472	+0.832	.003	.005	3	4
LUNG_SCLC	BAG6 →	+0.407	+0.786	.001	.009	3	4
BLOOD_Myeloma	HNRNPLL →	+0.894	+1.355	.003	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

S100PBP by Regulation of positive chemotaxis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →