Regulation of positive chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of positive chemotaxis pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FPR2, DDX52, and RBP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FPR2 grouped by Regulation of positive chemotaxis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FPR2 →	-0.167	-0.215	.004	.004	3	6
LUNG_SCLC	DDX52 →	+0.246	+0.133	.005	.003	3	5
LUNG_NSCLC_LUSC	RBP4 →	+0.182	+0.304	.004	.002	3	5
LUNG_NSCLC_LUSC	SUPV3L1 →	-0.268	-0.288	<.001	.004	3	5
LARGE_INTESTINE	GPR183 →	+0.157	+0.133	.007	.004	3	4
OESOPHAGUS	YAP1 →	+0.181	+0.321	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FPR2 by Regulation of positive chemotaxis activity — OESOPHAGUS

Explore this box plot interactively →