Positive regulation of chemotaxis

Across TCGA patient cohorts, RNA activity of the Positive regulation of chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RA, SELPLG, and AIF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chemotaxis activity versus CSF2RA in UCEC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CSF2RA →	+0.789	+0.239	<.001	<.001	3	10
OV	SELPLG →	+1.168	+0.229	<.001	<.001	3	9
GBM	AIF1 →	+1.068	+0.277	.009	.005	3	9
UCEC	NCF4 →	+0.702	+0.148	.002	.005	3	8
UCEC	CD4 →	+0.811	+0.276	<.001	<.001	2	9
UCEC	BTK →	+0.834	+0.211	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050921 vs CSF2RA — UCEC

Explore this scatter interactively →