Positive regulation of chemotaxis

Across TCGA cell cohorts, RNA activity of the Positive regulation of chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN5, ZMAT3, and PIK3R3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEPTIN5 grouped by Positive regulation of chemotaxis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SEPTIN5 →	+1.811	+0.545	.003	.008	2	4
SOFT_TISSUE	ZMAT3 →	-1.194	-1.488	.004	<.001	3	3
CNS	PIK3R3 →	+0.971	+0.567	.001	.005	2	4
CNS	TBC1D3L →	+1.244	+0.832	<.001	<.001	3	3
URINARY_TRACT	RGPD8 →	+1.307	+0.381	.004	.006	3	3
BLOOD_Myeloma	BTD →	-0.483	-0.919	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEPTIN5 by Positive regulation of chemotaxis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →