Positive regulation of chemotaxis

Across TCGA cell cohorts, RNA activity of the Positive regulation of chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C19orf54, NFKB1, and ZBTB5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chemotaxis activity versus C19orf54 in BLOOD_Leukemia (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C19orf54 →	+0.687	+0.195	.004	.001	3	5
STOMACH	NFKB1 →	+0.851	+0.260	.006	.002	3	5
STOMACH	ZBTB5 →	-0.824	-0.271	.007	.003	3	4
BONE	IL6R →	-2.204	-0.217	<.001	<.001	3	4
OESOPHAGUS	SPSB3 →	+0.988	+0.159	.003	.001	3	4
LUNG_SCLC	RAB3IL1 →	-1.759	-0.295	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050921 vs C19orf54 — BLOOD_Leukemia

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