Regulation of chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC47A1, HOXB7, and WDTC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chemotaxis activity versus SLC47A1 in SOFT_TISSUE (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC47A1 →	-2.570	-0.233	<.001	.002	3	6
SKIN	HOXB7 →	+0.892	+0.202	.004	<.001	3	5
LUNG_SCLC	WDTC1 →	+0.792	+0.193	<.001	.007	3	5
BLOOD_Lymphoma	IL6R →	-2.630	-0.212	.002	.002	3	5
LUNG_SCLC	CPSF4 →	+0.557	+0.199	.001	.004	3	5
UPPER_AERODIGESTIVE_TRACT	MCM7 →	+1.418	+0.214	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050920 vs SLC47A1 — SOFT_TISSUE

Explore this scatter interactively →