Positive chemotaxis

Across TCGA patient cohorts, RNA activity of the Positive chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MS4A4A, GINS2, and LINC00676, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive chemotaxis activity versus MS4A4A in LSCC (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MS4A4A →	+0.555	+0.079	.003	.002	3	4
GBM	GINS2 →	-0.801	-0.151	<.001	.001	3	4
GBM	LINC00676 →	+0.721	+0.124	.005	.004	3	4
GBM	HMGB3 →	-0.664	-0.149	.001	.002	3	4
LUAD	PGRMC1 →	-0.399	-0.181	<.001	.009	3	3
COAD	GALNT10 →	-0.462	-0.125	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050918 vs MS4A4A — LSCC

Explore this scatter interactively →