Positive chemotaxis

Across TCGA cell cohorts, RNA activity of the Positive chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXJ2, HLA-DQA1, and STBD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOXJ2 grouped by Positive chemotaxis-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FOXJ2 →	+0.967	+1.282	<.001	<.001	3	4
BREAST	HLA-DQA1 →	+0.219	+0.780	.006	.001	3	4
LUNG_SCLC	STBD1 →	-1.850	-1.073	.001	.002	3	4
SKIN	GPSM3 →	-1.005	-0.744	.003	.003	3	4
LUNG_NSCLC_LUSC	RPS24 →	+0.783	+0.823	.001	.007	3	3
STOMACH	YEATS2 →	+0.573	+0.252	.009	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOXJ2 by Positive chemotaxis activity — KIDNEY

Explore this box plot interactively →