Positive chemotaxis

Across TCGA cell cohorts, RNA activity of the Positive chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A4, MIF, and PSME1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive chemotaxis activity versus S100A4 in PANCREAS (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	S100A4 →	+5.051	+0.250	.004	.008	2	13
LARGE_INTESTINE	MIF →	+1.835	+0.215	<.001	<.001	3	10
LUNG_NSCLC_LUAD	PSME1 →	+1.542	+0.208	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	ANP32A →	+2.448	+0.358	<.001	<.001	3	9
LARGE_INTESTINE	PPIA →	+1.978	+0.181	<.001	.001	3	9
STOMACH	PTPN11 →	+1.354	+0.440	.003	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050918 vs S100A4 — PANCREAS

Explore this scatter interactively →