Sensory perception of sour taste

Across TCGA patient cohorts, RNA activity of the Sensory perception of sour taste pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB3D, SRGAP2, and KRT19, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sensory perception of sour taste activity versus RAB3D in HNSC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RAB3D →	+0.613	+0.604	<.001	<.001	3	6
OV	SRGAP2 →	-0.244	-0.073	<.001	.001	3	5
UCEC	KRT19 →	+0.568	+0.147	<.001	<.001	3	5
OV	SNX9 →	-0.335	-0.085	<.001	.002	2	6
OV	HAPLN3 →	-0.642	-0.107	<.001	<.001	3	5
OV	LLGL2 →	+0.810	+0.116	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050915 vs RAB3D — HNSC

Explore this scatter interactively →