Sensory perception of sour taste

Across TCGA cell cohorts, RNA activity of the Sensory perception of sour taste pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BECN1, HSD17B7, and MCF2L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BECN1 grouped by Sensory perception of sour taste-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BECN1 →	-0.373	-1.450	.005	.001	3	4
SKIN	HSD17B7 →	-0.887	-1.344	.007	<.001	3	4
LUNG_SCLC	MCF2L →	-3.078	-1.456	.008	.004	2	5
LUNG_NSCLC_LUAD	C2CD5 →	-0.835	-0.909	<.001	.002	3	3
OESOPHAGUS	EPC2 →	-0.597	-1.430	.005	.004	3	3
OESOPHAGUS	PEX11A →	-0.790	-1.725	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BECN1 by Sensory perception of sour taste activity — LARGE_INTESTINE

Explore this box plot interactively →