Sensory perception of sour taste

Across TCGA cell cohorts, RNA activity of the Sensory perception of sour taste pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OPN1MW, AATF, and KCNJ12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OPN1MW grouped by Sensory perception of sour taste-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OPN1MW →	+0.100	+1.140	<.001	<.001	3	4
OESOPHAGUS	AATF →	+0.131	+1.198	.007	.006	3	4
LUNG_NSCLC_LUAD	KCNJ12 →	+0.166	+0.934	<.001	.002	3	4
PANCREAS	ZNF440 →	+0.352	+0.474	.001	.002	3	4
CNS	YES1 →	-0.167	-1.052	.008	.001	3	4
SOFT_TISSUE	CHST4 →	+0.276	+1.387	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OPN1MW by Sensory perception of sour taste activity — BREAST

Explore this box plot interactively →