Neuromuscular process

Across TCGA patient cohorts, RNA activity of the Neuromuscular process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCDC80, RNASE1, and SMARCD2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuromuscular process activity versus CCDC80 in PDAC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CCDC80 →	+0.640	+0.022	<.001	<.001	3	8
BRCA	RNASE1 →	+0.728	+0.019	<.001	<.001	3	7
GBM	SMARCD2 →	-0.276	-0.053	<.001	<.001	3	7
BRCA	SRPX2 →	+0.848	+0.015	<.001	<.001	3	7
BRCA	C1R →	+0.582	+0.021	<.001	<.001	3	7
LSCC	CHERP →	-0.208	-0.022	.003	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050905 vs CCDC80 — PDAC

Explore this scatter interactively →