Neuromuscular process

Across TCGA cell cohorts, RNA activity of the Neuromuscular process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS25, POLR3G, and NT5C1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuromuscular process activity versus VPS25 in LUNG_NSCLC_LUSC (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	VPS25 →	+0.510	+0.216	.003	.006	3	4
URINARY_TRACT	POLR3G →	-1.896	-0.270	.002	.001	3	4
PANCREAS	NT5C1B →	+0.184	+0.178	.006	.004	2	5
URINARY_TRACT	UTP6 →	-0.558	-0.258	.004	.002	3	4
BONE	ODC1 →	-1.322	-0.334	.001	.002	3	3
URINARY_TRACT	SRM →	-1.217	-0.286	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050905 vs VPS25 — LUNG_NSCLC_LUSC

Explore this scatter interactively →