Diapedesis

Across TCGA patient cohorts, RNA activity of the Diapedesis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMKR1, PRDM8, and TRGJ2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diapedesis activity versus SMKR1 in CCRCC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SMKR1 →	-0.758	-0.481	<.001	.007	3	4
BRCA	PRDM8 →	+0.445	+0.138	.002	.004	3	3
HNSC	TRGJ2 →	+1.069	+0.116	.002	.002	3	3
CCRCC	NME1 →	-0.458	-0.431	<.001	.001	3	3
PDAC	CD164L2 →	-0.301	-0.184	.007	.001	3	3
UCEC	BRI3BP →	-0.511	-0.316	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050904 vs SMKR1 — CCRCC

Explore this scatter interactively →