Leukocyte tethering or rolling

Across TCGA patient cohorts, RNA activity of the Leukocyte tethering or rolling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASAL3, CYTIP, and ARHGAP9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte tethering or rolling activity versus RASAL3 in OV (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RASAL3 →	+0.823	+0.633	.002	<.001	3	8
HNSC	CYTIP →	+1.013	+0.655	<.001	<.001	3	8
GBM	ARHGAP9 →	+0.766	+0.262	<.001	<.001	3	8
GBM	NCKAP1L →	+1.068	+0.282	<.001	<.001	3	8
OV	LILRB2 →	+1.059	+0.585	<.001	<.001	3	8
GBM	PIK3R5 →	+1.080	+0.265	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050901 vs RASAL3 — OV

Explore this scatter interactively →