Leukocyte tethering or rolling

Across TCGA cell cohorts, RNA activity of the Leukocyte tethering or rolling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX1B, ZEB1, and NMNAT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STX1B grouped by Leukocyte tethering or rolling-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	STX1B →	-0.861	-1.158	.001	.001	3	6
URINARY_TRACT	ZEB1 →	-2.796	-1.587	.002	.007	3	5
LUNG_NSCLC_LUSC	NMNAT1 →	-1.206	-1.550	.001	.004	2	6
LUNG_NSCLC_LUSC	FAM83E →	+1.383	+1.038	.004	.006	3	5
LUNG_NSCLC_LUSC	HSPA13 →	-1.488	-1.021	<.001	.007	3	5
LARGE_INTESTINE	AGR2 →	+4.048	+0.891	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STX1B by Leukocyte tethering or rolling activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →