Leukocyte tethering or rolling

Across TCGA cell cohorts, RNA activity of the Leukocyte tethering or rolling pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB1, SLC25A33, and NPDC1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte tethering or rolling activity versus ITGB1 in LIVER (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ITGB1 →	+1.988	+0.201	<.001	.001	3	9
SKIN	SLC25A33 →	-0.925	-0.277	.001	.009	2	8
BONE	NPDC1 →	-3.148	-0.502	.006	.001	3	6
PANCREAS	RSAD1 →	-1.277	-0.339	<.001	.001	3	6
BONE	PSORS1C1 →	+1.738	+0.474	<.001	<.001	3	6
BREAST	CCT3 →	-0.970	-0.346	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050901 vs ITGB1 — LIVER

Explore this scatter interactively →