Intestinal absorption

Across TCGA patient cohorts, RNA activity of the Intestinal absorption pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLS1, KRT18, and BCAS1_S399, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal absorption activity versus PLS1 in UCEC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLS1 →	+0.522	+0.077	<.001	<.001	3	8
GBM	KRT18 →	+0.525	+0.062	.004	<.001	3	7
LUAD	BCAS1_S399 →	+1.187	+0.055	.006	.001	3	7
GBM	GALK2 →	+0.314	+0.053	<.001	.001	3	6
CCRCC	PLEKHA7_S903 →	+0.700	+0.068	<.001	<.001	3	6
HNSC	CMPK1 →	+0.310	+0.049	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050892 vs PLS1 — UCEC

Explore this scatter interactively →