Intestinal absorption

Across TCGA patient cohorts, RNA activity of the Intestinal absorption pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C4orf19, NLE1, and TFAP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal absorption activity versus C4orf19 in LUAD (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	C4orf19 →	+0.948	+0.173	<.001	.001	3	5
LSCC	NLE1 →	-0.550	-0.186	<.001	<.001	3	5
LSCC	TFAP4 →	-0.423	-0.153	.001	.005	3	5
COAD	PSMA2 →	-0.226	-0.142	<.001	.007	3	5
PDAC	QSER1 →	-0.247	-0.137	.006	.001	3	5
LSCC	CDK5RAP1 →	-0.368	-0.163	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050892 vs C4orf19 — LUAD

Explore this scatter interactively →