Intestinal absorption

Across TCGA cell cohorts, RNA activity of the Intestinal absorption pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPZL2, SOWAHB, and F11R, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal absorption activity versus MPZL2 in STOMACH (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MPZL2 →	+3.632	+0.375	.002	<.001	3	8
STOMACH	SOWAHB →	+1.265	+0.324	<.001	<.001	3	8
LUNG_NSCLC_LUAD	F11R →	+1.407	+0.225	<.001	<.001	3	8
STOMACH	DYRK3 →	-2.145	-0.422	<.001	<.001	3	7
LUNG_NSCLC_LUAD	HSH2D →	+2.179	+0.353	<.001	<.001	3	7
STOMACH	CHN1 →	-3.779	-0.447	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050892 vs MPZL2 — STOMACH

Explore this scatter interactively →