Multicellular organismal-level water homeostasis

Across TCGA patient cohorts, RNA activity of the Multicellular organismal-level water homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC4, ATAD2_S342, and UBE2O, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal-level water homeostasis activity versus RFC4 in LSCC (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC4 →	-0.453	-0.069	<.001	<.001	3	5
COAD	ATAD2_S342 →	-0.934	-0.047	<.001	<.001	3	5
LSCC	UBE2O →	-0.187	-0.049	<.001	<.001	3	5
LSCC	WDR36 →	-0.353	-0.079	<.001	<.001	3	5
COAD	WDR43_S77 →	-0.637	-0.034	.003	.001	3	5
COAD	LIG1 →	-0.262	-0.021	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050891 vs RFC4 — LSCC

Explore this scatter interactively →