Multicellular organismal-level water homeostasis

Across TCGA patient cohorts, RNA activity of the Multicellular organismal-level water homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARPBP, FBP1, and GLOD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal-level water homeostasis activity versus PARPBP in BRCA (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PARPBP →	-0.606	-0.707	.001	<.001	3	5
LSCC	FBP1 →	+0.717	+0.268	.002	.002	3	4
LSCC	GLOD5 →	+0.231	+0.204	<.001	.007	3	4
LSCC	UBQLNL →	+0.243	+0.233	.001	.005	3	4
LSCC	RNU7-45P →	+0.691	+0.296	<.001	.005	3	4
LSCC	AMY2B →	+0.411	+0.199	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050891 vs PARPBP — BRCA

Explore this scatter interactively →