Neuromuscular process controlling posture

Across TCGA patient cohorts, RNA activity of the Neuromuscular process controlling posture pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGCD, STXBP1, and SGCB, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuromuscular process controlling posture activity versus SGCD in GBM (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SGCD →	+0.490	+0.055	.003	<.001	3	7
GBM	STXBP1 →	+0.605	+0.054	.001	.001	3	7
LSCC	SGCB →	+0.223	+0.033	.004	.001	3	6
HNSC	TTI1 →	-0.197	-0.052	<.001	<.001	3	6
BRCA	ZCCHC24 →	+0.281	+0.036	.005	<.001	3	6
GBM	NUP160 →	-0.176	-0.063	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050884 vs SGCD — GBM

Explore this scatter interactively →