Neuromuscular process controlling posture

Across TCGA pan-cancer cohorts, RNA activity of the Neuromuscular process controlling posture pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Neuromuscular process controlling posture pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and CESC, show the opposite pattern, with higher activity associated with better survival.

KIRC, MESO, and OV are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.553	0.690	<.001	91	view →
MESO	OS	Tertile	II,III,IV	0.265	0.507	.007	69	view →
OV	OS	Median	IV	0.513	0.692	.016	32	view →
UCS	DFS	Median	IV	0.440	0.885	.015	30	view →
SKCM	DFS	Tertile	All	0.285	0.164	.001	25	view →
THYM	OS	Median	II,III,IV	0.855	1.000	.001	23	view →
LAML	DFS	Median	All	0.400	0.695	.001	22	view →
CESC	OS	Median	IV	0.897	0.339	.002	22	view →
BLCA	DFS	Median	All	0.207	0.513	.005	22	view →
LUAD	OS	Quartile	II,III,IV	0.672	0.466	.016	15	view →
READ	DFS	Tertile	All	0.256	0.774	.007	13	view →
SCLC	OS	Median	II,III,IV	0.415	0.698	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0050884–KIRC (DFS)

Open the KIRC breakdown →