Neuromuscular process controlling posture

Across TCGA patient cohorts, RNA activity of the Neuromuscular process controlling posture pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2Q1, KPNA2, and CDC45, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuromuscular process controlling posture activity versus UBE2Q1 in LSCC (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBE2Q1 →	-0.384	-0.453	.002	.006	3	5
COAD	KPNA2 →	-0.373	-0.137	.002	.006	3	4
LSCC	CDC45 →	-0.592	-0.441	.002	.003	2	5
PDAC	EIF3H →	-0.306	-0.132	.002	.008	3	4
LSCC	NDUFS2 →	-0.307	-0.457	.005	.002	3	4
LSCC	PRR14L →	-0.491	-0.518	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050884 vs UBE2Q1 — LSCC

Explore this scatter interactively →