White fat cell differentiation

Across TCGA patient cohorts, RNA activity of the White fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INAVA, SFMBT1, and PDZPH1P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, White fat cell differentiation activity versus INAVA in GBM (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	INAVA →	+0.809	+0.236	<.001	.007	3	3
GBM	SFMBT1 →	+0.293	+0.215	.005	.003	3	3
BRCA	PDZPH1P →	+0.577	+0.591	.004	<.001	3	3
LUAD	RNU6-1099P →	+0.450	+0.327	.002	.007	3	3
LUAD	CTBP2P2 →	+0.110	+0.419	.005	.002	3	3
BRCA	TAS2R39 →	+0.056	+0.731	.007	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050872 vs INAVA — GBM

Explore this scatter interactively →