Negative regulation of B cell activation

Across TCGA patient cohorts, RNA activity of the Negative regulation of B cell activation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF9, ITK, and PLA2G2D, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell activation activity versus TNFRSF9 in UCEC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TNFRSF9 →	+1.087	+0.978	<.001	<.001	3	9
UCEC	ITK →	+0.981	+0.909	<.001	<.001	3	8
UCEC	PLA2G2D →	+1.418	+0.735	.001	.001	3	8
GBM	SIGLEC10 →	+1.198	+1.207	<.001	<.001	3	8
UCEC	SLAMF6 →	+1.367	+0.908	<.001	<.001	3	8
UCEC	TRG-AS1 →	+0.798	+0.893	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050869 vs TNFRSF9 — UCEC

Explore this scatter interactively →