Positive regulation of T cell receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIT, TRIM22, and SERBP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell receptor signaling pathway activity versus CIT in CCRCC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CIT →	-0.741	-0.330	<.001	.006	3	3
HNSC	TRIM22 →	+0.971	+0.097	<.001	<.001	3	3
UCEC	SERBP1 →	-0.313	-0.387	.004	<.001	3	3
UCEC	THAP9 →	-0.484	-0.512	.002	<.001	3	3
UCEC	FTCDNL1 →	-0.455	-0.309	.006	.006	3	3
OV	PAXIP1-DT →	-0.526	-0.855	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050862 vs CIT — CCRCC

Explore this scatter interactively →