Positive regulation of T cell receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NECTIN2, ITGB5, and WFS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell receptor signaling pathway activity versus NECTIN2 in BREAST (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NECTIN2 →	+1.225	+1.151	.006	.001	3	6
LUNG_SCLC	ITGB5 →	+2.646	+0.536	<.001	.001	3	6
CNS	WFS1 →	+1.045	+0.937	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	SERPINE1 →	+3.149	+0.999	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	HSPD1 →	-1.082	-0.933	.005	.002	3	5
STOMACH	GABARAPL1 →	+2.851	+1.387	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050862 vs NECTIN2 — BREAST

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