Negative regulation of T cell receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of T cell receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF652, SOWAHC, and MED13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF652 grouped by Negative regulation of T cell receptor signaling pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF652 →	+0.924	+0.836	<.001	.008	3	4
LARGE_INTESTINE	SOWAHC →	-0.724	-0.941	.004	.008	3	4
OVARY	MED13 →	+0.712	+0.684	<.001	.009	3	3
UPPER_AERODIGESTIVE_TRACT	LSM2 →	+0.923	+1.101	.004	.003	3	3
PANCREAS	CIART →	+1.962	+1.426	.001	.001	3	3
PANCREAS	ZFYVE26 →	+0.539	+1.186	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF652 by Negative regulation of T cell receptor signaling pathway activity — OVARY

Explore this box plot interactively →