Negative regulation of antigen receptor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of antigen receptor-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKAP2, FKBP15, and AMPD3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of antigen receptor-mediated signaling pathway activity versus SKAP2 in GBM (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SKAP2 →	+0.704	+0.080	<.001	<.001	3	10
LSCC	FKBP15 →	+0.229	+0.087	<.001	<.001	3	10
GBM	AMPD3 →	+0.672	+0.089	<.001	<.001	3	10
GBM	LCP1 →	+0.826	+0.091	<.001	<.001	3	10
LSCC	RCSD1 →	+0.641	+0.113	<.001	<.001	3	9
OV	RENBP →	+0.431	+0.043	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050858 vs SKAP2 — GBM

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