Negative regulation of antigen receptor-mediated signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of antigen receptor-mediated signaling pathway pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 32 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Negative regulation of antigen receptor-mediated signaling pathway pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUAD and SKCM, show the opposite pattern, with higher activity associated with better survival.

ACC, LUAD, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.780	0.956	<.001	113	view →
LUAD	DFS	Median	All	0.752	0.588	<.001	99	view →
SKCM	OS	Median	All	0.424	0.282	<.001	60	view →
KIRP	DFS	Median	III,IV	0.191	0.867	<.001	58	view →
THCA	DFS	Median	III,IV	0.544	0.806	<.001	40	view →
HNSC	DFS	Quartile	III,IV	0.396	0.262	.007	33	view →
UVM	DFS	Median	II,III,IV	0.439	0.729	.002	31	view →
LIHC	DFS	Tertile	All	0.187	0.351	.004	23	view →
KIRC	OS	Quartile	All	0.526	0.727	<.001	20	view →
READ	OS	Tertile	III,IV	0.655	1.000	.002	20	view →
BRCA	OS	Median	II,III,IV	0.680	0.480	.005	18	view →
TGCT	DFS	Median	All	0.929	0.747	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0050858–ACC (OS)

Open the ACC breakdown →