Negative regulation of antigen receptor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of antigen receptor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF8, SELL, and LGALSL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of antigen receptor-mediated signaling pathway activity versus TNFSF8 in GBM (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNFSF8 →	+0.745	+0.125	<.001	.002	3	5
HNSC	SELL →	+1.172	+0.384	<.001	.003	3	5
LSCC	LGALSL →	-0.499	-0.274	.006	<.001	3	4
LSCC	LSM11 →	-0.360	-0.298	.001	.007	3	4
LSCC	CD3D →	+0.777	+0.252	<.001	.007	2	5
GBM	CD7 →	+0.259	+0.192	.007	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050858 vs TNFSF8 — GBM

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