Negative regulation of antigen receptor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of antigen receptor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTMR4, TRIM37, and AGL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTMR4 grouped by Negative regulation of antigen receptor-mediated signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MTMR4 →	+0.587	+0.887	.002	.002	3	4
LARGE_INTESTINE	TRIM37 →	+0.655	+1.025	.002	.002	3	4
LARGE_INTESTINE	AGL →	+0.641	+0.939	.001	.001	3	4
LARGE_INTESTINE	RAB12 →	+0.445	+0.901	.007	.001	3	4
LARGE_INTESTINE	ZNF184 →	+0.608	+1.038	.001	.003	3	4
OVARY	FOXK2 →	+0.540	+0.657	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTMR4 by Negative regulation of antigen receptor-mediated signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →