Negative regulation of antigen receptor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of antigen receptor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LANCL3, ADAMTS15, and IAH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of antigen receptor-mediated signaling pathway activity versus LANCL3 in SKIN (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LANCL3 →	-0.375	-0.192	.003	.006	3	4
LUNG_NSCLC_LUAD	ADAMTS15 →	-1.637	-0.192	<.001	<.001	3	4
LUNG_SCLC	IAH1 →	+0.477	+0.367	.005	.007	3	4
UPPER_AERODIGESTIVE_TRACT	ELOVL2 →	-0.319	-0.240	.004	.006	3	3
BREAST	TMEM45B →	+1.853	+0.237	.004	.007	3	3
BONE	PIK3R2 →	+1.113	+0.403	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050858 vs LANCL3 — SKIN

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