Antigen receptor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Antigen receptor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYRK3, S100A14, and HLA-B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen receptor-mediated signaling pathway activity versus DYRK3 in OVARY (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DYRK3 →	+1.425	+0.450	<.001	.008	3	4
BREAST	S100A14 →	-6.100	-0.322	<.001	<.001	3	4
LUNG_SCLC	HLA-B →	+3.093	+0.194	.005	.002	3	4
BONE	CERKL →	+1.644	+0.199	.002	.008	3	4
BREAST	ANGPTL6 →	+0.467	+0.167	.005	.005	3	4
LUNG_NSCLC_LUSC	MED11 →	+0.468	+0.185	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050851 vs DYRK3 — OVARY

Explore this scatter interactively →