Positive regulation of calcium-mediated signaling

Across TCGA patient cohorts, RNA activity of the Positive regulation of calcium-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLA, CCDC141, and GVINP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcium-mediated signaling activity versus SLA in LSCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLA →	+0.788	+0.255	<.001	<.001	3	6
LSCC	CCDC141 →	+0.807	+0.280	<.001	<.001	3	6
LSCC	GVINP1 →	+1.046	+0.275	<.001	<.001	3	6
LUAD	E2F1 →	-1.024	-0.130	<.001	<.001	3	5
GBM	PPP1R16B →	+1.088	+0.196	<.001	<.001	3	5
LUAD	BRCA1 →	-0.882	-0.143	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050850 vs SLA — LSCC

Explore this scatter interactively →