Positive regulation of calcium-mediated signaling

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of calcium-mediated signaling pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 42 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Positive regulation of calcium-mediated signaling pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

HNSC, SKCM, and CHOL are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.416	0.260	.001	85	view →
SKCM	OS	Quartile	All	0.451	0.264	<.001	74	view →
CHOL	DFS	Median	All	0.768	0.116	<.001	49	view →
THCA	DFS	Tertile	All	0.899	0.977	.001	33	view →
CESC	DFS	Tertile	All	0.814	0.648	.005	32	view →
KIRP	DFS	Median	IV	0.039	0.593	.008	30	view →
LUAD	DFS	Quartile	II,III,IV	0.587	0.294	.016	26	view →
ACC	DFS	Quartile	III,IV	0.185	0.649	.003	24	view →
SARC	OS	Median	All	0.725	0.476	.003	24	view →
THYM	DFS	Median	All	0.733	0.940	.021	19	view →
TGCT	DFS	Quartile	II,III,IV	0.544	0.996	.033	18	view →
OV	DFS	Median	III,IV	0.128	0.178	.022	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0050850–HNSC (DFS)

Open the HNSC breakdown →